The various Examples of Tricyclic antidepressants are among the earliest antidepressants developed. Albeit they have generally been replaced by antidepressants that cause fewer side effects, tricyclic type of antidepressants are effective and may be a good option for some people. In certain cases, they relieve depression when other treatments have failed. Tricyclic or Cyclic antidepressants ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Cyclic antidepressants block the reuptake of the neurotransmitters serotonin and norepinephrine, increasing the levels of these two neurotransmitters in the brain. It also affect other chemical messengers, which can lead to a number of side effects.

Examples of Tricyclic antidepressants approved by the Food and Drug Administration (FDA) to treat depression include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, and Trimipramine. Other conditions that can be treated using this type of antidepressants other than depression include obsessive-compulsive disorder, anxiety disorders or nerve-related (neuropathic) pain. Some common possible side effects are Drowsiness, Blurred vision, Constipation, Dry mouth, Urine retention, and Drop in blood pressure when moving from sitting to standing, which can cause lightheadedness. Other possible side effects include Weight loss, Increased appetite leading to weight gain, Excessive sweating, Tremor, and Sexual problems, such as difficulty achieving an erection, delayed orgasm or low sex drive.

Amitriptyline, doxepin, imipramine and trimipramine are more likely to one sleepy than other antidepressants are. Therefore, it is recommended that they be taken at bedtime. Similarly, Amitriptyline, doxepin, imipramine and trimipramine are more likely to cause weight gain than other tricyclic antidepressants are. In the same way, Nortriptyline and desipramine have better tolerated side effects than other antidepressants in the tricyclic category do. For antidepressants that cause sleepiness, be careful about doing activities that require you to be alert, such as driving a car, until you know how the medication will affect you. The best antidepressant for patients depends on a number of issues, such as your symptoms and any other health conditions you may have. APA